CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor X isoform 1

Enzyme Information

3.4.21.6
Coagulation factor Xa.
based on mapping to UniProt P00742
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
-!- A blood coagulation factor formed from the proenzyme factor X by limited proteolysis. -!- Factor X is a glycoprotein composed of a heavy chain and a light chain, which are generated from a precursor protein by the excision of the tripeptide RKR and held together by one or more disulfide bonds. -!- The activated factor Xa converts prothrombin to thrombin in the presence of factor Va, Ca(2+) and phospholipids. -!- Scutelarin (EC 3.4.21.60) has similar specificity, but does not require factor Va. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00742
FA10_HUMAN
Homo sapiens
Coagulation factor X

PDB Structure

PDB 3KL6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a tetrahydropyrimidin-2(1H)-one derivative (TAK-442) as a potent, selective, and orally active factor Xa inhibitor.
Fujimoto, T., Imaeda, Y., Konishi, N., Hiroe, K., Kawamura, M., Textor, G.P., Aertgeerts, K., Kubo, K.
J.Med.Chem.