CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.470 | D-amino Acid Aminotransferase; Chain A, domain 1 |
|
3.30.470.20 | ATP-grasp fold, B domain |
Domain Context
CATH Clusters
| Superfamily | ATP-grasp fold, B domain |
| Functional Family | Pyruvate carboxylase subunit A |
Enzyme Information
| 6.3.4.14 |
Biotin carboxylase.
based on mapping to UniProt P24182
ATP + biotin-[carboxyl-carrier-protein] + HCO(3)(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
|
| 6.4.1.2 |
Acetyl-CoA carboxylase.
based on mapping to UniProt P24182
ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.
-!- Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.
|
UniProtKB Entries (1)
| P24182 |
ACCC_ECOLI
Escherichia coli K-12
Biotin carboxylase
|
PDB Structure
| PDB | 3JZI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery and optimization of antibacterial AccC inhibitors.
Bioorg.Med.Chem.Lett.
|