CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.129
Endo-alpha-sialidase.
based on mapping to UniProt Q04830
Endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids.
-!- Although the name endo-N-acetylneuraminidase has also been used for this enzyme, this is misleading since its activity is not restricted to acetyl-substituted substrates. -!- An exo-alpha-sialidase activity is listed as EC 3.2.1.18. -!- See also 4.2.2.15.

UniProtKB Entries (1)

Q04830
FIBER_BPK1F
Enterobacteria phage K1F
Tail spike protein

PDB Structure

PDB 3GVJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF.
Schulz, E.C., Schwarzer, D., Frank, M., Stummeyer, K., Muhlenhoff, M., Dickmanns, A., Gerardy-Schahn, R., Ficner, R.
J.Mol.Biol.