CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Protein-tyrosine kinase HTK98, variant

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00523
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523
SRC_CHICK
Gallus gallus
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 3GEQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Comparative analysis of mutant tyrosine kinase chemical rescue.
Muratore, K.E., Seeliger, M.A., Wang, Z., Fomina, D., Neiswinger, J., Havranek, J.J., Baker, D., Kuriyan, J., Cole, P.A.
Biochemistry