CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Tyrosine-protein kinase (Capsular polysaccharide biosynthesis) |
Enzyme Information
| 2.7.10.- |
Protein-tyrosine kinases.
based on mapping to UniProt P38134
|
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P38134
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| P38134 |
ETK_ECOLI
Escherichia coli K-12
Tyrosine-protein kinase etk
|
PDB Structure
| PDB | 3CIO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Escherichia coli tyrosine kinase Etk reveals a novel activation mechanism.
Embo J.
|