CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.4.-.-
Acting on peptide bonds (peptidases).
based on mapping to UniProt A8E0K8
3.4.16.4
Serine-type D-Ala-D-Ala carboxypeptidase.
based on mapping to UniProt A8E0K8
Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.
-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

A8E0K8
A8E0K8_HAEIF
Haemophilus influenzae
Penicillin-binding protein 4

PDB Structure

PDB 3A3E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae
Kawai, F., Clarke, T.B., Roper, D.I., Han, G.-J., Hwang, K.Y., Unzai, S., Obayashi, E., Park, S.-Y., Tame, J.R.H.
J.Mol.Biol.