CATH Domain 2yl2A03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1490	Dna Ligase; domain 1
	3.30.1490.20	ATP-grasp fold, A domain

Domain Context

CATH Clusters

Superfamily	ATP-grasp fold, A domain
Functional Family	Acetyl-CoA carboxylase, isoform A

Enzyme Information

6.3.4.14	Biotin carboxylase. based on mapping to UniProt Q13085 ATP + biotin-[carboxyl-carrier-protein] + HCO(3)(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].
6.4.1.2	Acetyl-CoA carboxylase. based on mapping to UniProt Q13085 ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA. -!- Also catalyzes transcarboxylation; the plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA.

UniProtKB Entries (1)

ACACA_HUMAN

Homo sapiens

Acetyl-CoA carboxylase 1

PDB Structure

PDB	2YL2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of Human Acetyl-Coa Carboxylase 1, Biotin Carboxylase (Bc) Domain Muniz, J.R.C., Froese, D.S., Krysztofinska, E., Vollmar, M., Beltrami, A., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W., Oppermann, U. To be Published