CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family Cation transporting P-type ATPase

Enzyme Information

3.6.3.8
Calcium-transporting ATPase.
based on mapping to UniProt P04191
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in Saccharomyces cerevisiae. -!- The first and third transport one ion per ATP hydrolyzed, whereas the second transports two ions. -!- Formerly EC 3.6.1.38.

UniProtKB Entries (1)

P04191
AT2A1_RABIT
Oryctolagus cuniculus
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB 2YFY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mutual Adaptation of a Membrane Protein and its Lipid Bilayer During Conformational Changes.
Sonntag, Y., Musgaard, M., Olesen, C., Schiott, B., Moller, J.V., Nissen, P., Thogersen, L.
Nat.Commun.