CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.670 |
Domain Context
CATH Clusters
Superfamily | 3.40.50.670 |
Functional Family | DNA gyrase subunit B |
Enzyme Information
5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P66937
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
5.99.1.3 |
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q99XG5
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- Can introduce negative superhelical turns into double-stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
|
UniProtKB Entries (1)
Q99XG5 |
GYRA_STAAN
Staphylococcus aureus subsp. aureus N315
DNA gyrase subunit A
|
PDB Structure
PDB | 2XCS |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Nature
|