1 keywords

CATH Domain 2x6fA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1010 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Homologous Superfamily 3.30.1010.10 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4
Functional Family Phosphatidylinositol 3-kinase, root isoform

Enzyme Information

2.7.1.137
Phosphatidylinositol 3-kinase.
based on mapping to UniProt Q9W1M7
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

Q9W1M7
Q9W1M7_DROME
Drosophila melanogaster
Phosphatidylinositol 3-kinase

PDB Structure

PDB 2X6F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Miller, S., Tavshanjian, B., Oleksy, A., Perisic, O., Houseman, B.T., Shokat, K.M., Williams, R.L.
Science