CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information
Type I protein arginine methyltransferase.
based on mapping to UniProt Q9WVG6
2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L- homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.
-!- This eukaryotic enzyme catalyzes the sequential dimethylation of one of the terminal guanidino nitrogen atoms in arginine residues, resulting in formation of asymmetric dimethylarginine residues. -!- Some forms (e.g. PRMT1) have a very wide substrate specificity, while others (e.g. PRMT4 and PRMT6) are rather specific. -!- The enzyme has a preference for methylating arginine residues that are flanked by one or more glycine residues. -!- PRMT1 is responsible for the bulk (about 85%) of total protein arginine methylation activity in mammalian cells. -!- Cf. EC, EC and EC -!- Formerly EC, EC, EC and EC

UniProtKB Entries (1)

Mus musculus
Histone-arginine methyltransferase CARM1

PDB Structure

PDB 2V74
External Links
Primary Citation
Insights Into Histone Code Syntax from Structural and Biochemical Studies of Carm1 Methyltransferase
Yue, W.W., Hassler, M., Roe, S.M., Thompson-Vale, V., Pearl, L.H.
Embo J.