CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family RAC-beta serine/threonine-protein kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31749
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31749
AKT1_HUMAN
Homo sapiens
RAC-alpha serine/threonine-protein kinase

PDB Structure

PDB 2UZR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Carpten, J.D., Faber, A.L., Horn, C., Donoho, G.P., Briggs, S.L., Robbins, C.M., Hostetter, G., Boguslawski, S., Moses, T.Y., Savage, S., Uhlik, M., Lin, A., Du, J., Qian, Y.W., Zeckner, D.J., Tucker-Kellogg, G., Touchman, J., Patel, K., Mousses, S., Bittner, M., Schevitz, R., Lai, M.H., Blanchard, K.L., Thomas, J.E.
Nature