CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Thioredoxin reductase 1, mitochondrial

Enzyme Information

1.8.1.9
Thioredoxin-disulfide reductase.
based on mapping to UniProt P91938
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

UniProtKB Entries (1)

P91938
TRXR1_DROME
Drosophila melanogaster
Thioredoxin reductase 1, mitochondrial

PDB Structure

PDB 2NVK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Biochemical Studies Reveal Differences in the Catalytic Mechanisms of Mammalian and Drosophila melanogaster Thioredoxin Reductases.
Eckenroth, B.E., Rould, M.A., Hondal, R.J., Everse, S.J.
Biochemistry