CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.160 | Double Stranded RNA Binding Domain |
|
3.30.160.20 |
Domain Context
CATH Clusters
| Superfamily | 3.30.160.20 |
| Functional Family | Double-stranded RNA-specific adenosine deaminase |
Enzyme Information
| 3.5.4.37 |
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.
|
UniProtKB Entries (1)
| P55265 |
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase
|
PDB Structure
| PDB | 2MDR |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.
Proc.Natl.Acad.Sci.USA
|