CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.10 | Roll | |
3.10.50 | Chitinase A; domain 3 | |
3.10.50.40 |
Domain Context
CATH Clusters
Superfamily | 3.10.50.40 |
Functional Family | Fkbp-type peptidyl-prolyl cis-trans isomerase |
Enzyme Information
5.2.1.8 |
Peptidylprolyl isomerase.
based on mapping to UniProt Q1HR83
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
|
UniProtKB Entries (1)
Q1HR83 |
Q1HR83_AEDAE
Aedes aegypti
Peptidylprolyl isomerase
|
PDB Structure
PDB | 2LPV |
External Links | |
Method | SOLUTION NMR |
Organism | |
Primary Citation |
Solution structure of FK506-binding protein 12 from Aedes aegypti.
Proteins
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