CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Functional Family Ubiquitin carboxyl-terminal hydrolase isozyme L1

Enzyme Information

6.-.-.-
Ligases.
based on mapping to UniProt P09936
3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt P09936
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P09936
UCHL1_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase isozyme L1

PDB Structure

PDB 2LEN
External Links
Method SOLUTION NMR
Organism
Primary Citation
Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1
Tse, H., Sze, K., Hu, H.
to be published