CATH Domain 2jkvA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.320	6-Phosphogluconate Dehydrogenase, domain 3

Domain Context

CATH Clusters

Superfamily	6-Phosphogluconate Dehydrogenase, domain 3
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P52209

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P52209

6PGD_HUMAN

Homo sapiens

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	2JKV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Human Phosphogluconate Dehydrogenase in Complex with Nadph at 2.53A Ng, S.S., von Delft, F., Pilka, E.S., Kavanagh, K.L., McDonough, M.A., Savitsky, P., Arrowsmith, C.H., Weigelt, J., Edwards, A., Sundstrom, M., Schofield, C.J., Oppermann, U. To be Published