CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.260 | Galactose-binding domain-like |
Domain Context
CATH Clusters
| Superfamily | Galactose-binding domain-like |
| Functional Family | Fusarium graminearum chromosome 3, complete genome |
Enzyme Information
| 3.2.1.52 |
Beta-N-acetylhexosaminidase.
based on mapping to UniProt Q0TR53
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
-!- Acts on N-acetylglucosides and N-acetylgalactosides. -!- Formerly EC 3.2.1.29 and EC 3.2.1.30.
|
| 3.2.1.169 |
Protein O-GlcNAcase.
based on mapping to UniProt Q0TR53
(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
|
UniProtKB Entries (1)
| Q0TR53 |
OGA_CLOP1
Clostridium perfringens ATCC 13124
O-GlcNAcase NagJ
|
PDB Structure
| PDB | 2J1A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Interaction of a Carbohydrate-Binding Module from a Clostridium Perfringens N-Acetyl-Beta-Hexosaminidase with its Carbohydrate Receptor
J.Biol.Chem.
|