CATH Classification

Domain Context

CATH Clusters

Superfamily Metalloenzyme, LuxS/M16 peptidase-like
Functional Family Insulin-degrading enzyme isoform 4

Enzyme Information

3.4.24.56
Insulysin.
based on mapping to UniProt P14735
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
-!- Cytosolic enzyme, known from mammals and Drosophila melanogaster. -!- Inhibited by bacitracin, chelating agents EDTA and 1,10- phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not by phosphoramidon. -!- Belongs to peptidase family M16. -!- Formerly EC 3.4.22.11, EC 3.4.99.10 and EC 3.4.99.45.

UniProtKB Entries (1)

P05067
A4_HUMAN
Homo sapiens
Amyloid beta A4 protein

PDB Structure

PDB 2G47
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Shen, Y., Joachimiak, A., Rosner, M.R., Tang, W.J.
Nature