CATH Classification
Domain Context
CATH Clusters
| Superfamily | Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2 |
| Functional Family | 6-hydroxy-D-nicotine oxidase |
Enzyme Information
| 1.5.3.6 |
(R)-6-hydroxynicotine oxidase.
based on mapping to UniProt Q8GAG1
(R)-6-hydroxynicotine + H(2)O + O(2) = 1-(6-hydroxypyridin-3-yl)-4- (methylamino)butan-1-one + H(2)O(2).
-!- The enzyme, which participates in nicotine degradation, is specific for (R) isomer of 6-hydroxynicotine, derived from the uncommon (R)- nicotine. -!- The bacterium Arthrobacter nicotinovorans, in which this enzyme was originally discovered, has a different enzyme that catalyzes a similar reaction with the (S)-isomer (cf. EC 1.5.3.5).
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UniProtKB Entries (1)
| Q8GAG1 |
Q8GAG1_PAENI
Paenarthrobacter nicotinovorans
6-hydroxy-D-nicotine oxidase
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PDB Structure
| PDB | 2BVF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of 6-Hydroxy-D-Nicotine Oxidase from Arthrobacter Nicotinovorans.
J.Mol.Biol.
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