CATH Classification

Domain Context

CATH Clusters

Superfamily Acetylglutamate kinase-like
Functional Family Aspartate/glutamate/uridylate kinase family protein

Enzyme Information

2.7.4.22
UMP kinase.
based on mapping to UniProt Q8U122
ATP + UMP = ADP + UDP.
-!- Strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme EC 2.7.4.14 for the same purpose. -!- Subject of feedback regulation, being inhibited by UTP and activated by GTP.

UniProtKB Entries (1)

Q8U122
PYRH_PYRFU
Pyrococcus furiosus DSM 3638
Uridylate kinase

PDB Structure

PDB 2BRX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of Pyrococcus Furiosus Ump Kinase Provides Insight Into Catalysis and Regulation in Microbial Pyrimidine Nucleotide Biosynthesis.
Marco-Marin, C., Gil-Ortiz, F., Rubio, V.
J.Mol.Biol.