CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.340 | Nitric Oxide Synthase; Chain A, domain 1 |
|
3.90.340.10 | Nitric Oxide Synthase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Nitric Oxide Synthase; Chain A, domain 1 |
| Functional Family | Nitric oxide synthase, inducible |
Enzyme Information
| 1.14.13.39 |
Nitric-oxide synthase (NADPH).
based on mapping to UniProt P29473
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
-!- This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. -!- Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. -!- May produce superoxide under certain conditions. -!- Cf. EC 1.14.13.165.
|
UniProtKB Entries (1)
| P29473 |
NOS3_BOVIN
Bos taurus
Nitric oxide synthase, endothelial
|
PDB Structure
| PDB | 1ZZS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Exploring the Binding Conformations of Bulkier Dipeptide Amide Inhibitors in Constitutive Nitric Oxide Synthases.
Biochemistry
|