CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Blood coagulation factor II

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P02671
FIBA_HUMAN
Homo sapiens
Fibrinogen alpha chain

PDB Structure

PDB 1YCP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Malkowski, M.G., Martin, P.D., Lord, S.T., Edwards, B.F.
Biochem.J.