CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 1W2K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design of Selective Phenylglycine Amide Tissue Factor/Factor Viia Inhibitors
Groebke-Zbinden, K., Banner, D.W., Ackermann, J., D'Arcy, A., Kirchhofer, D., Ji, Y.-H., Tschopp, T.B., Wallbaum, S., Weber, L.
Bioorg.Med.Chem.Lett.