CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.60 | 4-Layer Sandwich |
|
3.60.10 | Deoxyribonuclease I; Chain A |
|
3.60.10.10 | Endonuclease/exonuclease/phosphatase |
Domain Context
CATH Clusters
| Superfamily | Endonuclease/exonuclease/phosphatase |
| Functional Family | LINE-1 retrotransposable element ORF2 protein |
Enzyme Information
| 3.1.21.- |
Endodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt O00370
|
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt O00370
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
UniProtKB Entries (1)
| O00370 |
LORF2_HUMAN
Homo sapiens
LINE-1 retrotransposable element ORF2 protein
|
PDB Structure
| PDB | 1VYB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon.
Structure
|