CATH Classification

Domain Context

CATH Clusters

Superfamily Rieske [2Fe-2S] iron-sulphur domain
Functional Family Cytochrome b-c1 complex subunit Rieske

Enzyme Information

1.10.2.2
Quinol--cytochrome-c reductase.
based on mapping to UniProt P13272
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and C(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).

UniProtKB Entries (1)

P31800
QCR1_BOVIN
Bos taurus
Cytochrome b-c1 complex subunit 1, mitochondrial

PDB Structure

PDB 1SQB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex
Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
J.Mol.Biol.