CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.970 | Thiamin diphosphate (ThDP)-binding fold, Pyr/PP domains |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.970 |
| Functional Family | Pyruvate decarboxylase isozyme 1 |
Enzyme Information
| 4.1.1.- |
Carboxy-lyases.
based on mapping to UniProt P06169
|
| 4.1.1.43 |
Phenylpyruvate decarboxylase.
based on mapping to UniProt P06169
Phenylpyruvate = phenylacetaldehyde + CO(2).
-!- Also acts on (indol-3-yl)pyruvate.
|
| 4.1.1.1 |
Pyruvate decarboxylase.
based on mapping to UniProt P06169
A 2-oxo acid = an aldehyde + CO(2).
-!- Also catalyzes acyloin formation.
|
| 4.1.1.74 |
Indolepyruvate decarboxylase.
based on mapping to UniProt P06169
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
-!- More specific than EC 4.1.1.1.
|
UniProtKB Entries (1)
| P06169 |
PDC1_YEAST
Saccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 1
|
PDB Structure
| PDB | 1PVD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
J.Mol.Biol.
|