CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Pyruvate decarboxylase isozyme 1

Enzyme Information

4.1.1.-
Carboxy-lyases.
based on mapping to UniProt P06169
4.1.1.43
Phenylpyruvate decarboxylase.
based on mapping to UniProt P06169
Phenylpyruvate = phenylacetaldehyde + CO(2).
-!- Also acts on (indol-3-yl)pyruvate.
4.1.1.74
Indolepyruvate decarboxylase.
based on mapping to UniProt P06169
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
-!- More specific than EC 4.1.1.1.
4.1.1.1
Pyruvate decarboxylase.
based on mapping to UniProt P06169
A 2-oxo acid = an aldehyde + CO(2).
-!- Also catalyzes acyloin formation.

UniProtKB Entries (1)

P06169
PDC1_YEAST
Saccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 1

PDB Structure

PDB 1PVD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
Arjunan, P., Umland, T., Dyda, F., Swaminathan, S., Furey, W., Sax, M., Farrenkopf, B., Gao, Y., Zhang, D., Jordan, F.
J.Mol.Biol.