CATH Domain 1p6nA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1230	Bovine Endothelial Nitric Oxide Synthase Heme Domain; Chain: A,domain 3
	3.90.1230.10	Nitric Oxide Synthase; Chain A, domain 3

Domain Context

CATH Clusters

Superfamily	Nitric Oxide Synthase; Chain A, domain 3
Functional Family

Enzyme Information

1.14.13.39

Nitric-oxide synthase (NADPH).

based on mapping to UniProt P29473

2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.

-!- This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. -!- Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. -!- May produce superoxide under certain conditions. -!- Cf. EC 1.14.13.165.

UniProtKB Entries (1)

P29473

NOS3_BOVIN

Bos taurus

Nitric oxide synthase, endothelial

PDB Structure

PDB	1P6N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Pichia
Primary Citation	Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Flinspach, M.L., Li, H., Jamal, J., Yang, W., Huang, H., Hah, J.M., Gomez-Vidal, J.A., Litzinger, E.A., Silverman, R.B., Poulos, T.L. Nat.Struct.Mol.Biol.