CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.440 | Nitric Oxide Synthase;Heme Domain; Chain A, domain 2 | |
3.90.440.10 | Nitric Oxide Synthase;Heme Domain;Chain A domain 2 |
Domain Context
CATH Clusters
Superfamily | Nitric Oxide Synthase;Heme Domain;Chain A domain 2 |
Functional Family | Nitric oxide synthase, endothelial |
Enzyme Information
1.14.13.39 |
Nitric-oxide synthase (NADPH).
based on mapping to UniProt P29473
2 L-arginine + 3 NADPH + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.
-!- This eukaryotic enzyme, which is found in plants and animals, consists of oxygenase and reductase domains that are linked via a regulatory calmodulin-binding domain. -!- Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. -!- May produce superoxide under certain conditions. -!- Cf. EC 1.14.13.165.
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UniProtKB Entries (1)
P29473 |
NOS3_BOVIN
Bos taurus
Nitric oxide synthase, endothelial
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PDB Structure
PDB | 1P6N |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Pichia |
Primary Citation |
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nat.Struct.Mol.Biol.
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