CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1820
Functional Family Probable dipeptidyl peptidase 4

Enzyme Information

3.4.14.5
Dipeptidyl-peptidase IV.
based on mapping to UniProt P22411
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
-!- A membrane-bound serine-type peptidase in mammals. -!- EC 3.4.14.11 catalyzes a similar reaction. -!- Belongs to peptidase family S9B.

UniProtKB Entries (1)

P22411
DPP4_PIG
Sus scrofa
Dipeptidyl peptidase 4

PDB Structure

PDB 1ORV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism
Engel, M., Hoffmann, T., Wagner, L., Wermann, M., Heiser, U., Kiefersauer, R., Huber, R., Bode, W., Demuth, H.U., Brandstetter, H.
Proc.Natl.Acad.Sci.USA