CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NAD(P) transhydrogenase subunit alpha

Enzyme Information

1.6.1.2
NAD(P)(+) transhydrogenase (Re/Si-specific).
based on mapping to UniProt Q2RSB2
NADPH + NAD(+) = NADP(+) + NADH.
-!- The enzyme from heart mitochondria is Re-specific with respect to NAD(+) and Si-specific with respect to NADP(+) (cf. EC 1.6.1.1.).

UniProtKB Entries (1)

Q2RSB4
PNTB_RHORT
Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit beta

PDB Structure

PDB 1NM5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Glutamine 132 in the NAD(H)-binding component of proton-translocating transhydrogenase tethers the nucleotides before hydride transfer.
van Boxel, G.I., Quirk, P.G., Cotton, N.P., White, S.A., Jackson, J.B.
Biochemistry