CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Probable methylisocitrate lyase 2

Enzyme Information

4.1.3.30
Methylisocitrate lyase.
based on mapping to UniProt P77541
(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate.
-!- Acts on threo-D(s)-2-methylisocitrate, but not on threo-D(s)- isocitrate, threo-DL-isocitrate or erythro-L(s)-isocitrate.

UniProtKB Entries (1)

P77541
PRPB_ECOLI
Escherichia coli K-12
2-methylisocitrate lyase

PDB Structure

PDB 1MUM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre.
Grimm, C., Evers, A., Brock, M., Maerker, C., Klebe, G., Buckel, W., Reuter, K.
J.Mol.Biol.