CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family L-threonine 3-O-phosphate decarboxylase

Enzyme Information

4.1.1.81
Threonine-phosphate decarboxylase.
based on mapping to UniProt P97084
L-threonine O-3-phosphate = (R)-1-aminopropan-2-yl phosphate + CO(2).
-!- Unable to decarboxylate the D-isomer of threonine O-3-phosphate. -!- The product of this reaction, (R)-1-aminopropan-2-yl phosphate, is the substrate of EC 6.3.1.10, which converts adenosylcobyric acid into adenosylcobinamide phosphate in the anaerobic cobalamin biosynthesis pathway.

UniProtKB Entries (1)

P97084
COBD_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Threonine-phosphate decarboxylase

PDB Structure

PDB 1LC7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural studies of the L-threonine-O-3-phosphate decarboxylase (CobD) enzyme from Salmonella enterica: the apo, substrate, and product-aldimine complexes.
Cheong, C.G., Escalante-Semerena, J.C., Rayment, I.
Biochemistry