CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1310.10
Functional Family Replication protein E1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03116
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03116
VE1_BPV1
Bovine papillomavirus type 1
Replication protein E1

PDB Structure

PDB 1KSY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex.
Enemark, E.J., Stenlund, A., Joshua-Tor, L.
EMBO J.