CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.238 | Recoverin; domain 1 | |
1.10.238.10 | EF-hand |
Domain Context
CATH Clusters
Superfamily | EF-hand |
Functional Family |
Enzyme Information
2.7.11.19 |
Phosphorylase kinase.
based on mapping to UniProt P62158
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
-!- Requires calmodulin for activity. -!- The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. -!- For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. -!- The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b. -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit. -!- Formerly EC 2.7.1.38.
|
UniProtKB Entries (1)
P40136 |
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase
|
PDB Structure
PDB | 1K90 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Nature
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