CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.132 | Topoisomerase I; Chain A, domain 4 |
|
1.10.132.10 |
Domain Context
CATH Clusters
| Superfamily | 1.10.132.10 |
| Functional Family | DNA topoisomerase I, mitochondrial |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P11387
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| P11387 |
TOP1_HUMAN
Homo sapiens
DNA topoisomerase 1
|
PDB Structure
| PDB | 1K4T |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Spodoptera |
| Primary Citation |
The mechanism of topoisomerase I poisoning by a camptothecin analog
Proc.Natl.Acad.Sci.USA
|