CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aminoglycoside phosphotransferase

Enzyme Information

2.7.1.95
Kanamycin kinase.
based on mapping to UniProt P0A3Y5
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.

UniProtKB Entries (1)

P0A3Y5
KKA3_ENTFL
Enterococcus faecalis
Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB 1J7I
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase.
Burk, D.L., Hon, W.C., Leung, A.K., Berghuis, A.M.
Biochemistry