CATH Classification

Domain Context

CATH Clusters

Superfamily DNA-directed RNA polymerase, insert domain
Functional Family RNA polymerase alpha subunit

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q5SHR6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q8RQE9
RPOB_THET8
Thermus thermophilus HB8
DNA-directed RNA polymerase subunit beta

PDB Structure

PDB 1IW7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
Vassylyev, D.G., Sekine, S., Laptenko, O., Lee, J., Vassylyeva, M.N., Borukhov, S., Yokoyama, S.
NATURE