CATH Domain 1guzB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Domain Context

CATH Clusters

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family	Malate dehydrogenase, cytoplasmic 1

Enzyme Information

1.1.1.37	Malate dehydrogenase. based on mapping to UniProt B3QPY9 (S)-malate + NAD(+) = oxaloacetate + NADH. -!- Also oxidizes some other 2-hydroxydicarboxylic acids.
1.1.1.37	Malate dehydrogenase. based on mapping to UniProt P80039 (S)-malate + NAD(+) = oxaloacetate + NADH. -!- Also oxidizes some other 2-hydroxydicarboxylic acids.

UniProtKB Entries (2)

B3QPY9	MDH_CHLP8 Chlorobaculum parvum NCIB 8327 Malate dehydrogenase
P80039	MDH_CHLTE Chlorobium tepidum TLS Malate dehydrogenase

PDB Structure

PDB	1GUZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases Dalhus, B., Saarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H. J.Mol.Biol.