CATH Classification

Domain Context

CATH Clusters

Superfamily HUPs
Functional Family Probable methionine--tRNA ligase, mitochondrial

Enzyme Information

6.1.1.10
Methionine--tRNA ligase.
based on mapping to UniProt P00959
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.

UniProtKB Entries (1)

P00959
SYM_ECOLI
Escherichia coli K-12
Methionine--tRNA ligase

PDB Structure

PDB 1F4L
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding.
Serre, L., Verdon, G., Choinowski, T., Hervouet, N., Risler, J.L., Zelwer, C.
J.Mol.Biol.