CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.140 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.140 |
| Functional Family | DNA topoisomerase 1 |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P06612
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| P06612 |
TOP1_ECOLI
Escherichia coli K-12
DNA topoisomerase 1
|
PDB Structure
| PDB | 1ECL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I.
Nature
|