CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Thymidylate synthase, isoform CRA_b

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P0A884
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P0A884
TYSY_ECOLI
Escherichia coli K-12
Thymidylate synthase

PDB Structure

PDB 1DNA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Sage, C.R., Michelitsch, M.D., Stout, T.J., Biermann, D., Nissen, R., Finer-Moore, J., Stroud, R.M.
Biochemistry