CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Cystathionine gamma-synthase, PLP-dependent

Enzyme Information

2.5.1.48
Cystathionine gamma-synthase.
based on mapping to UniProt P00935
O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate.
-!- Also reacts with H(2)S and methanethiol as replacing agents, producing homocysteine and methionine, respectively. -!- In the absence of thiol, can also catalyze beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia. -!- Formerly EC 4.2.99.9.

UniProtKB Entries (1)

P00935
METB_ECOLI
Escherichia coli K-12
Cystathionine gamma-synthase

PDB Structure

PDB 1CS1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution.
Clausen, T., Huber, R., Prade, L., Wahl, M.C., Messerschmidt, A.
EMBO J.