CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family Class C beta-lactamase CMY-10

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P00811
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P00811
AMPC_ECOLI
Escherichia coli K-12
Beta-lactamase

PDB Structure

PDB 1C3B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The complexed structure and antimicrobial activity of a non-beta-lactam inhibitor of AmpC beta-lactamase.
Powers, R.A., Blazquez, J., Weston, G.S., Morosini, M.I., Baquero, F., Shoichet, B.K.
Protein Sci.