CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family | Thymidylate synthase, isoform CRA_b |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt P00469
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
UniProtKB Entries (1)
| P00469 |
TYSY_LACCA
Lactobacillus casei
Thymidylate synthase
|
PDB Structure
| PDB | 1BO7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry
|