CATH Classification

Domain Context

CATH Clusters

Superfamily Creatinase/methionine aminopeptidase superfamily
Functional Family Methionine aminopeptidase 1, mitochondrial

Enzyme Information
Methionyl aminopeptidase.
based on mapping to UniProt P50579
Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
-!- This membrane-bound enzyme, which is present in both prokaryotes and eukaryotes, releases the initiator methionine from nascent peptides. -!- The activity is dependent on the identity of the second, third and fourth amino acid residues of the target protein, but in general the enzyme acts only when the penultimate residue is small and uncharged (e.g. Gly, Ala, Cys, Ser, Thr, and Val). -!- Belongs to peptidase family M24A.

UniProtKB Entries (1)

Homo sapiens
Methionine aminopeptidase 2

PDB Structure

PDB 1B59
External Links
Organism Nucleopolyhedrovirus
Primary Citation
Structure of human methionine aminopeptidase-2 complexed with fumagillin.
Liu, S., Widom, J., Kemp, C.W., Crews, C.M., Clardy, J.