CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Beta-galactoside-specific lectin 4

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P11140
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P11140
ABRA_ABRPR
Abrus precatorius
Abrin-a

PDB Structure

PDB 1ABR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of abrin-a at 2.14 A.
Tahirov, T.H., Lu, T.H., Liaw, Y.C., Chen, Y.L., Lin, J.Y.
J.Mol.Biol.