CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.170 | Beta Complex | |
2.170.11 | DNA Topoisomerase I; domain 2 | |
2.170.11.10 | DNA Topoisomerase I, domain 2 |
Domain Context
CATH Clusters
Superfamily | DNA Topoisomerase I, domain 2 |
Functional Family | Mitochondrial DNA topoisomerase I |
Enzyme Information
5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P11387
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
P11387 |
TOP1_HUMAN
Homo sapiens
DNA topoisomerase 1
|
PDB Structure
PDB | 1A36 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Spodoptera |
Primary Citation |
A model for the mechanism of human topoisomerase I.
Science
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