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CATH Superfamily 3.90.70.50

Streptopain (SpeB)

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peptidase C10, streptopain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Streptopain (SpeB)

This entry represents streptopain (or SpeB), a highly conserved secreted cysteine protease that is found in the majority of S. pyogenes strains. Production, secretion, and activation of SpeB is highly regulated, and its proteolytic activity has been linked to immunomodulating activities during infectionPMID:22645124. The substrates for the enzyme have been extensively investigated, and during infection, SpeB demonstrates a broad substrate tolerance and, in an attempt to circumvent the immune system, degrades a multitude of proteins, such as interleukins, immunoglobulins, integrins and antimicrobial peptides. SpeB belongs to clan CA (of the MEROPS database) and therefore exhibits a papain-like fold PMID:19712682.

PMID:22645124 PMID:19712682

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
588 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 18
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 4
Unique PDBs: 10
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC: 1
Unique GO: 1
Taxonomy
Unique Species: 588